Beilstein J. Org. Chem.2022,18, 1322–1331, doi:10.3762/bjoc.18.137
prediction of two C2 related, dominating binding sites on 14-3-3ζ that may bind to two of the supramolecular ligand molecules.
Keywords: AIEluminophores; fluorescence emission; guanidiniocarbonyl-pyrrole; ligand binding; 14-3-3 protein; Introduction
The 14-3-3 protein family was one of the first
[15][18]. In contrast to classical luminophores, these compounds typically show emission “on” behavior upon aggregation or binding, which can be explained by a restriction of motion. In this contribution, we designed a hybrid compound featuring AIEluminophores based on aromatic thioethers [19] as a
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Graphical Abstract
Figure 1:
AIE-active molecule 1. (a) Structure of 1 with color-coded subunits AIE, lysine, and GCP. (b) Coars...